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マンザミンAの全合成 Chem-Station (ケムステ)

5 days ago Total synthesis of (+)-manzamine a toma,t.; kita, y.; fukuyama, t. j. am. chem. soc. 2010, 132, 10233. doi:10.1021/ja103721s 海洋性アルカロイド・マンザミンaはその特異な5環性主骨格(6-6-5-15-8システム)に加えて、多様な生物活性(細胞毒性、抗菌活性、抗マラリア、駆虫作用、抗炎症、抗hiv)を示すため、世界中の合成化学者の

Url: https://www.chem-station.com/blog/2010/08/--a.html

DA: 20 PA: 22 MOZ Rank: 44

Manzamine A CAS 104196-68-1 SCBT - Santa Cruz

14 days ago Manzamine a is a β-carboline alkaloid isolated from the marine sponge xestospongia ashmorica that acts as a gsk-3β inhibitor. the compound is reported to have activity against the gram-positive bacteria: staphylococcus aureus and bacillus subtilis.malaria studies report manzamine a to block the asexual erythrocytic stage of plasmodium berghei.

Url: https://www.scbt.com/p/manzamine-a-104196-68-1/

DA: 12 PA: 27 MOZ Rank: 42

Manzamine A, a natural product derived from certain groups

1 months ago Manzamine a, a natural product derived from certain groups of sponges, can block the growth of cervical cancer cells, report researchers. manzamine a targets a protein that is highly expressed in many cancers, including cervical cancer, and is the first reported inhibitor of this protein.

Url: https://www.reddit.com/r/science/comments/fv9bog/manzamine_a_a_natural_product_derived_from/

DA: 14 PA: 50 MOZ Rank: 89

Manzamine dictionary definition manzamine defined

21 days ago Manzamine definition: noun (plural manzamines) 1. (organic chemistry) any of several polycyclic alkaloids, obtained from several species of sea sponge, that exhibit antimicrobial and antileukemic activity

Url: https://www.yourdictionary.com/manzamine

DA: 22 PA: 10 MOZ Rank: 38

Total Synthesis of (+)-Manzamine A Journal of the

1 months ago A novel synthetic route to (+)-manzamine a was developed. it highlights an amazingly efficient construction of a highly strained 15-membered ring across a cyclohexenone ring with the aim of installing the requisite functionalities in a completely stereocontrolled manner. other key features include a stereoselective diels−alder reaction of an optically active butenolide, construction of the

Url: https://pubs.acs.org/doi/10.1021/ja103721s

DA: 12 PA: 22 MOZ Rank: 41

Manzamine A - an overview ScienceDirect Topics

17 days ago Manzamine a (65) was first isolated from okinawan haliclona sp. as a cytotoxic compound against p-388 mouse leukemia cells, 236 and over 50 analogs have been discovered up to now. 237 significant in vitro and in vivo antimalarial activities of manzamine a and (−)-8-hydroxymanzamine a were reported in 2000 238; both compounds were also

Url: https://www.sciencedirect.com/topics/chemistry/manzamine-a

DA: 21 PA: 29 MOZ Rank: 58

Jeffrey D. Winkler Department of Chemistry

9 days ago New synthetic pathways based on the intramolecular dioxenone and vinylogous amide photocycloaddition reactions. we have developed these methods and have applied them to the first total syntheses of several molecules of biological importance, including manzamine a, 1, saudin, 2 , and ingenol, 3.

Url: https://www.chem.upenn.edu/profile/jeffrey-d-winkler

DA: 18 PA: 26 MOZ Rank: 53

Manzamine alkaloids: isolation, cytotoxicity, antimalarial

1 months ago Manzamine a was the first compound of this group isolated from okinawa sponge in 1986 . currently more than 100 manzamine natural alkaloids have been isolated from more than 16 species of marine sponges belonging to five families distributed from the red sea to indonesia.

Url: https://www.sciencedirect.com/science/article/pii/S135964461400244X

DA: 21 PA: 38 MOZ Rank: 69

Manzamine A CAS#104196-68-1 vacuolar ATPase uncoupler

4 days ago Manzamine a is a vacuolar atpase uncoupler and gsk-3 inhibitor found in marine sponges. it inhibits autophagy and tumor growth in cancer models, suppresses foam cell formation in macrophages, prevents growth of gram positive and gram negative bacteria, and decreases tau hyperphosphorylation.

Url: https://www.medkoo.com/products/15521

DA: 14 PA: 15 MOZ Rank: 40

Manzamine A Exerts Anticancer Activity against Human

1 months ago Marine drugs article manzamine a exerts anticancer activity against human colorectal cancer cells li-chun lin 1,†, tzu-ting kuo 2,†, hsin-yi chang 3 id, wen-shan liu 2, shih-min hsia 4,5,6 id and tsui-chin huang 1,2,7,* 1 ph.d. program for cancer molecular biology and drug discovery, college of medical science and technology, taipei medical university and academia sinica, taipei 11031

Url: https://www.mdpi.com/1660-3397/16/8/252/pdf

DA: 12 PA: 23 MOZ Rank: 47

Manzamine A 104196-68-1 - Order from Adipogen

7 days ago Manzamine a (keramamine a), 104196-68-1, is high purity chemical. isolated from xestospongia sp. antibiotic. autophagy inhibitor. gsk-3beta inhibitor. anti-alzheimer’s agent. anti-hyperlipidemic. anti-atherosclerotic. antimalaria and antiviral agent.

Url: https://adipogen.com/ag-cn2-0438-manzamine-a.html

DA: 12 PA: 29 MOZ Rank: 55

Manzamine Alkaloids - Modern Alkaloids - Wiley Online Library

3 months ago Manzamine alkaloids from marine sponges β‐carboline‐containing manzamine alkaloids manzamine a type. manzamine b type. manzamine c type. other β‐carboline‐containing manzamines. ircinal‐related alkaloids. source and large‐scale preparation of manzamine alkaloids

Url: https://onlinelibrary.wiley.com/doi/10.1002/9783527621071.ch8

DA: 23 PA: 30 MOZ Rank: 68

Manzamine A, a novel antitumor alkaloid from a sponge

3 months ago Manzamine b and e and ircinal a related alkaloids from an indonesian acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and alzheimer's diseases. journal of natural products 2006 , 69 (7) , 1034-1040.

Url: https://pubs.acs.org/doi/abs/10.1021/ja00280a055

DA: 12 PA: 28 MOZ Rank: 56

Daily Manab Zamin:: The World's First and Largest

1 days ago Bangladesh-based tabloid daily newspaper, ranked in the top 500 in the world, offering the latest politics, entertainment and sports news from around the globe.

Url: http://mzamin.com/

DA: 10 PA: 10 MOZ Rank: 28

US20050244938A1 - Manzamine-producing actinomycetes

16 days ago Us20050244938a1 us10/522,454 us52245405a us2005244938a1 us 20050244938 a1 us20050244938 a1 us 20050244938a1 us 52245405 a us52245405 a us 52245405a us 2005244938 a1 us2005244938 a1 us 2005244938a1 authority us united states prior art keywords manzamine actinomycete seq id isolated bacteria prior art date 2002-08-01 legal status (the legal status is an assumption and is not a legal conclusion.

Url: https://patents.google.com/patent/US20050244938A1/en

DA: 18 PA: 26 MOZ Rank: 63

Manzamine A - Reciprocal Net Common Molecule

1 months ago Manzamine a hydrochloride is an antitumor alkaloid found within a sponge. chemical formula: c 36 h 45 n 4 o 1 1+ layman's explanation: manzamine a was first revealed when scientists were trying to find antitumor activity in marine organisms. it was found that an extract from a sponge did in fact inhibit the growth of p388 mouse leukemia cells.

Url: http://www.reciprocalnet.org/recipnet/showsamplebasic.jsp?sampleId=27344561

DA: 21 PA: 29 MOZ Rank: 70

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